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The results of these studies are mixed, and due to study design, it is difficult to draw comparisons or firm conclusions (see Table 5 in the supplementary data for a summary of the evidence)

Figure 4 shows the results of SURPASS-4 by tirzepatide dose as well as for all doses pooled, compared to insulin glargine treatment

oral) and the pronounced fluctuations in systemic drug concentrations

PMID 30506340

Since the mean/median duration for each of these studies was 100,000 patients prescribed a GLP-1RA, after propensity matching, there was reduced risk for PDAC during a 5-year observation period for GLP-1RA users compared to six categories of commonly used diabetes medication classes 44

2023;15: eadg3049